Methylergometrine is a drug to prevent and treat bleedingpostpartum (postpartum). This drug can also be used to treat bleeding after a miscarriage.
Methylergometrine is also known as methylergonovine or methergine. This drug works by stimulating the uterine muscles to contract more strongly. As the contractions increase, the bleeding will also stop more quickly.
Trademark Methylergometrine: Methylergometrine Maleate, Bledstop, Pospargin, Morgin, Metiagin, Myotonic
What is Maprotiline
| group | Ergot alkaloids |
| Category | Prescription drugs |
| Benefit | Overcoming postpartum bleeding |
| Used by | Mature |
| Methylergometrine for pregnant and lactating women | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. Methylergometrine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Tablets, injections |
Precautions Before Using Methylergometrine
Methylergometrine should not be used carelessly and must be prescribed by a doctor. There are several things that must be considered before using this drug, including:
- Do not use methylergometrine if you are allergic to this drug.
- Do not consume alcoholic beverages while on treatment with methylergometrine.
- Do not drive or do activities that require alertness after taking methylergometrine.
- Tell your doctor if in this or previous pregnancies you have hypertension, preeclampsia, or eclampsia. This medicine should not be used in patients with these conditions.
- Tell your doctor if you have or are currently suffering from kidney disease, liver disease, heart and blood vessel disease, diabetes, or high cholesterol.
- Tell your doctor if you plan to have any dental treatment or surgery while taking methylergometrine.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- See a doctor immediately if you have an allergic reaction to the drug or an overdose after using m
Dosage and Instructions for Use of Methylergometrine
The dose of methylergometrine will be adjusted according to the form of the drug and the patient's condition. The following are the dosages of methylergometrine for adults, grouped by form of the drug:
Tablet
The dose of methylergometrine to prevent postpartum bleeding is 0.2 mg, which can be given 3-4 times a day, for 2-7 days.
Injections through the muscle (IM/intramuscular)
The dose to prevent and treat postpartum bleeding or bleeding after miscarriage is 0.2 mg. The dose can be repeated every 2–4 hours, up to a maximum of 5 times.
Injection through a vein (IV/intravenous)
The dose to prevent and treat postpartum bleeding or bleeding after miscarriage is 0.2 mg given by slow injection. The dose can be repeated every 2–4 hours, up to a maximum of 5 times.
How to Use Methylergometrine Correctly
Follow the doctor's recommendations and read the instructions for use listed on the packaging before using methylergometrine. Methylergometrine injection type is only given by a doctor or medical officer under the supervision of a doctor.
For methylergometrine tablets, take them at the same time every day, for maximum benefits. If you forget to take it, it is advisable to consume it as soon as you remember it, if the break with the next schedule is not too close. If it is close, ignore it and do not double the dose.
Store methylergometrine at room temperature. Do not store it in a humid place or in direct sunlight. Keep this medicine out of reach of children.
Methylergometrine Interactions with Other Drugs
The use of methylergometrine together with CYP3A4 inhibitors can cause drug interactions in the form of increasing blood levels of CYP3A4 blocking drugs and the risk of blood vessel constriction. Some examples of CYP3A4 inhibitors are:
- Macrolide antibiotics, such as erythromycin, clarithromycin, and troleandomycin
- Antifungals, including itraconazole, ketoconazole, and fluconazole
- HIV protease inhibitor class of antivirals, such as ritonavir, indinavir, and nelfinavir
- Antidepressants, including nefazodone, fluoxetine, and fluvoxamine
In addition, the use of methylergometrine with grape juice can also increase the risk of side effects.
Methylergometrine Side Effects and Dangers
Some of the side effects that may appear after using methylergometrine are:
- Nausea and vomiting
- Stomach ache
- Headache
- Dizzy
Check with your doctor if the side effects above don't go away or get worse. See your doctor immediately if you have an allergic reaction to the drug or a more serious side effect, such as:
- Severe headache
- Blurred vision
- Dizzy and want to faint
- Ears ringing
- Dazed or confused
- Regular heart rate
- Hard to breathe
- Chest pain
- Fingers or toes feel cold, tingling or swollen
- Seizures