Dobutamine is a drug to help the heart work in pumping blood throughout the body in people who experience heart failure or cardiogenic shock. UTo treat cardiogenic shock, this drug can be used with dopamine.
Dobutamine works by stimulating the heart's beta-1 receptors, thereby increasing heart contraction and the heart's pumping ability. This way of working will increase blood pressure, heart rate, and the amount of blood that will be pumped by the heart.cardiac output).
The use of this drug can only be done in a hospital and its administration will be carried out by a doctor or medical officer under the supervision of a doctor.
Dobutamine trademark: Cardiotone, Dobutamine HCL, Dobutamine-hameln, Domine, Dobuject
What is Dobutamine
| group | Prescription drugs |
| Category | heart medicine |
| Benefit | Help pump the heart |
| Used by | Adults and children |
| Dobutamine for pregnant and lactating women | Category B: Animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women. Dobutamine is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Inject |
Precautions Before Using Dobutamine
There are several things you should pay attention to before using dobutamine, including:
- Tell your doctor about any allergies you have. Dobutamine should not be given to patients who are allergic to this drug.
- Tell your doctor if you have or have had high blood pressure, valvular heart disease, heart infection, cardiomyopathy, angina, pheochromocytoma, asthma, hyperthyroidism, or glaucoma.
- Tell your doctor if you have any conditions that increase your risk of developing hypovolemia, such as severe, persistent vomiting or diarrhea or gastrointestinal bleeding.
- Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- See your doctor right away if you have an allergic drug reaction, serious side effect, or overdose after taking dobutamine.
Dosis and Dobutamine Use Rules
Dobutamine will be given by a doctor or medical officer under the supervision of a doctor by injection into a vein (intravenous / IV).
The initial dose of dobutamine for heart failure in adults is 2.5–10 mcg/kgBW per minute. The dose can be adjusted to 0.5–40 mcg/kg per minute, depending on the patient's response.
Meanwhile, the dose for infants to children aged 18 years is 5 mcg/kgBW per minute. The dose can be adjusted to 2–20 mcg/kgBW per minute, depending on the patient's response.
How to Use Dobutamine Correctly
Dobutamine will be given in the hospital. The injection will be directly carried out by a doctor or medical officer under the supervision of a doctor. Follow the doctor's advice and recommendations while undergoing treatment with dobutamine.
During treatment with dobutamine, the doctor will monitor blood pressure, heart rate, cardiac output, and the amount of urine output.
Dobutamine Interactions with Other Drugs
The following are some of the effects of interactions that may occur if dobutamine is used together with other drugs:
- Increased risk of hypotension and tachycardia when used with alpha-blocking drugs, such as phenoxybenzamine
- Increased effect and dobutamine levels when used with MAOI or tricyclic antidepressants
- Increased blood pressure when used with antihypertensive drugs
- Increased risk of dobutamine side effects when used with entacapone
- Increased risk of drug poisoning when used with ergotamine, methysergide, or ergometrine
- Increased risk of arrhythmias if used with quinidine, cardiac glycoside drugs, cyclopropane, or halothane.
- Increased risk of severe hypertension and bradycardia when used with beta-blocking drugs
- Enhanced effect of dobutamine when used with oxytocin
Dobutamine Side Effects and Dangers
Dobutamine will be given in the hospital. Tell your doctor or medical officer if the following side effects do not subside or get worse:
- Headache
- Fever
- Nausea or vomiting
- Feeling restless
- leg cramps
- Pain, swelling, or discoloration of the skin at the injection site
Report to your doctor if you have an allergic drug reaction or experience more serious side effects, such as:
- Chest pain
- Heart palpitations, fast heartbeat, or irregular heartbeat
- Headache so severe or dizzy that you feel like passing out
- Blurred vision
- Anxious or confused
- Seizures