Pantoprazole is a drug to relieve complaints and symptoms due to increased stomach acid, such as abdominal pain, heartburn (heartburn).heartburn), or difficulty swallowing. It is also used in the treatment of peptic ulcers, gastroesophageal reflux disease(GERD), Zollinger-Ellison syndrome, or esophagitis erosive.
Pantoprazole works by inhibiting the production of stomach acid. With reduced stomach acid, complaints due to increased stomach acid can subside. In addition, with reduced gastric acid production, ulcers (ulcers) in the stomach and erosion of the esophagus can also be prevented.
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What is Pantoprazole
| group | Prescription drugs |
| Category | Proton pump inhibitor |
| Benefit | Reduces stomach acid production |
| Used by | Adults, seniors, and children 5 years old |
| Pantoprazole for pregnant and lactating women | Category B: Animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women. Pantoprazole may be absorbed into breast milk. Therefore, breastfeeding mothers are advised to consult a doctor before using this drug, so that the doctor can weigh the benefits with the risks. |
| Drug form | Injectable liquid, tablets (enteric-coated and film-coated) |
Precautions Before Using Pantoprazole
Pantoprazole should not be used carelessly. Before using this drug, you need to pay attention to the following points:
- Tell your doctor if you are allergic to pantoprazole or other proton pump inhibitor medicines, such as esomeprazole, lansoprazole, omeprazole, and rabeprazole.
- Tell your doctor about your medical history, especially if you have or are currently suffering from hypomagnesemia, stomach cancer, lupus, kidney disease, osteoporosis, or liver disease.
- Tell your doctor if you are taking any other medicines, including supplements and herbal products.
- Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
- If an allergic reaction to the drug or an overdose occurs after using pantoprazole, see a doctor immediately.
Dosage and Rules for Use of Pantoprazole
Pantoprazole should only be used as prescribed by a doctor. The following are general doses of pantoprazole based on their intended use:
Purpose: Treating Zollinger-Ellison syndrome
Shape: Tablet
- Mature:40 mg, 2 times a day. Dosage can be adjusted up to 240 mg per day. Daily doses >80 mg need to be divided into 2 separate doses.
Purpose: Treating GERD (gastroesophageal reflux disease) or acid reflux disease
Shape: Tablet
- Mature:20–40 mg daily, for 4 weeks, may be continued for up to 8 weeks. The maintenance dose is 20–40 mg per day.
Purpose: Treat gastric ulcer or duodenal ulcer
Shape: Tablet
- Mature: 40 mg, once daily in the morning, for 2–4 weeks for duodenal ulcers. As for gastric ulcers, the duration of treatment is 4-8 weeks.
Purpose: Treating erosive esophagitis
Shape: Tablet
- Mature: 20–40 mg, once daily in the morning, for 4 weeks. The duration of treatment can be increased to 8 weeks if necessary.
- Children uage 5 years weight 15–40 kg: 20 mg, once daily for up to 8 weeks of treatment.
- Children uage 5 years body weight >40 kg: 40 mg, once daily for up to 8 weeks of treatment.
Purpose: Prevent gastric ulcers caused by non-steroidal anti-inflammatory drugs
Shape: Tablet
- Mature: 20 mg, once daily.
How to Use Pantoprazole Correctly
Follow the doctor's advice and read the information on the medicine package before using pantoprazole.
Pantoprazole in tablet form can be taken before or after meals. Take pantoprazole tablets whole with water. Do not crush, chew, or split the tablet as this may reduce the effectiveness of the drug.
Avoid some foods or drinks that can worsen symptoms related to acid reflux, such as spicy foods, hot drinks, alcoholic beverages, coffee, chocolate, and tomatoes. In addition, also avoid smoking.
Especially for gastric acid reflux, being overweight can make symptoms worse. Therefore, for those of you who are overweight or obese, it is advisable to lose weight and eat healthy foods to help relieve symptoms.
Try to take pantoprazole tablets at the same time every day, for maximum effect.
If you forget to take pantoprazole tablets, it is advisable to do it immediately if the break with the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
Store pantoprazole in a dry place, away from direct sunlight, and out of reach of children.
Pantoprazole Interaksi Interactions with Drug Other
Drug interactions that can occur if pantoprazole is used together with other drugs are:
- Decreased concentrations and levels of rilpivirine or atazanavir
- Elevated levels or cardiotoxic effects of digoxin
- Increased risk of developing hypomagnesaemia when used with diuretic drugs
- INR increase (international normalized ratio) and blood clotting time of warfarin
- Increased levels of methotrexate in the blood
- Decreased therapeutic effect of clopidogrel
- Decreased absorption of ketoconazole, itraconazole, posaconazole, or erlotinib
Side Effects and Dangers of Pantoprazole
Side effects that may appear after using pantoprazole include:
- Headache
- Bloated
- Stomach ache
- Constipation
- Hard to sleep
- Diarrhea
Consult a doctor if the above side effects do not subside immediately or get worse. You need to see a doctor immediately if you experience an allergic drug reaction or more serious side effects, such as low levels of vitamin B12, impaired liver function, or hypomagnesemia characterized by irregular heartbeat, muscle stiffness, and seizures.