Domperidone is drug for relieve nausea and throw up. This drug is available in the form of 10 mg tablets, syrup, and drops. Dosis medicine is necessary adjusted for age and condition suffered.
Domperidone works by speeding up the movement of the digestive tract, so that food in the stomach goes faster to the intestines. As a result, nausea can be reduced.
In addition to nausea and vomiting, domperidone can be used to treat digestive disorders, such as gastroparesis. Domperidone can also be used to stimulate or increase milk production.
Regardless of its efficacy, the use of domperidone should be carried out in accordance with the doctor's advice because of the risk of disturbing the heart rhythm, especially in elderly patients.
Trademark domperidone: Domperidone, Domperidone Maleate, Motilium, Gerdilium, Vesperum, Vomitas, Domeran, Vidon.
What is Domperidone?
| group | Antiemetic (antiemetic) |
| Category | Prescription drugs |
| Benefit | Relieves nausea and vomiting, and stimulates milk production. |
| Used by | Adults and children |
| Pregnancy and breastfeeding category | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the benefits outweigh the risks to the fetus. Domperidone is absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Tablets, syrup, drop (mouth drops). |
Warning Before Taking Domperidone
- Be careful using domperidone if you have kidney problems, liver problems, heart disease, electrolyte disturbances, tumors in the pituitary gland, and bleeding or blockages in the digestive system.
- Before using domperidone, tell your doctor if you have any allergies to any food, medicine, or any of the ingredients in this medicine.
- Be careful using domperidone if you have a history of breast cancer and are lactose intolerant.
- Tell your doctor if your symptoms do not improve or if they get worse after taking domperidone.
- Call your doctor immediately if you have an allergic reaction to the drug or an overdose.
Dose and Rules of Use Domperidone
The following is a general dosage of domperidone based on the condition you want to treat:
Condition: nausea and vomiting
- Adults: 10 mg, 3 times daily.
- Children: ≤12 year or <35 kg 250 mcg, 3 times a day. The maximum dose is 750 mcg/kg body weight a day.
Condition: Nausea and vomiting due to chemotherapy or radiotherapy
- Children: 0.2-0.4 mg/kg per day, every 4-8 hours.
Condition: stimulate milk production
- Initial dose 10 mg, 3 times a day. If after 7 days the results are not optimal, the dose can be increased to 20 mg, 3 times a day.
Method Taking Domperidone Correctly
Treatment with domperidone usually takes no more than 1 week. If 1 week has passed and the symptoms have not subsided, stop using domperidone and consult a doctor.
Make sure to always follow the doctor's recommendations and read the instructions on the drug packaging, when taking domperidone. The dose of the drug is given based on the patient's age, condition, and response to the drug.
Take this medicine 30 minutes before meals and before going to bed. Do not increase the dose of domperidone than your doctor prescribes. In addition to not making you heal faster, the risk of side effects will also increase.
When using domperidone in syrup form, use the spoon included in the package for the correct dosage, and do not use a tablespoon.
Store the domperidone in a place at room temperature, not in the refrigerator. Keep away from heat and direct sunlight. Do not use domperidone if the drug has expired.
Interaction Domperidone with Other Drugs
The following types of medicines can cause interactions when used together with domperidone:
- Bromocriptine, its effect inhibits the effectiveness of the drug.
- Opioid analgesics (eg morphine) and antimuscarinics (eg atropine), their effects inhibit the effectiveness of the drug domperidone.
- CYP3A4 inhibitors, such as ketoconazole or itraconazole, may increase the risk of heart rhythm disturbances.
Domperidone Side Effects and Dangers
Just like other drugs, domperidone can also cause side effects. Side effects that can arise from the use of domperidone are:
- Headache
- Feeling hot
- Red eye
- dry mouth
- Breast pain
- Milk coming out of the breast
- Breast swelling in men
- Menstrual disorders in women
Consult a doctor if these side effects persist. You also need to immediately see a doctor if you have complaints in the form of:
- Flying feeling
- Lost balance
- Faint
- Looks confused
- Heart beating fast
- Difficult to talk
These symptoms can be signs of a domperidone overdose.