Metronidazole is drug antibiotics to treat infections. This drug works by stopping the growth of various bacteria and parasites.
This antibiotic can only treat bacterial and parasitic infections, so it is not used to treat viral infections, such as the common cold or flu. Metronidazole can be used together with other medicines to treat bacterial infections H. Pylori.
TrademarkMetronidazole: Flagyl, Progyl, Trichodazole and Fladystin.
Drug InformationMetronidazole
| group | Antibiotics |
| Category | Prescription drugs |
| Benefit | Treat infections caused by bacteria or parasites in the reproductive system, digestive tract, skin, heart, bones, joints, lungs, blood, nervous system and other areas of the body. This drug is also useful for treating bacterial vaginosis in women. |
| Consumed by | Adults and children |
| Pregnancy and breastfeeding category | 1st trimesterCategory C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. 2nd and 3rd trimestersCategory B: Studies in animal studies have not shown any risk to the fetus, but there are no controlled studies in pregnant women. Metronodazole is absorbed into breast milk. Do not use this medication without telling your doctor. |
| Shape | Tablets, capsules, syrups, ovules, suppositories and infusions |
Warning BeforeUsing Metronidazole
- Tell your doctor if you have any allergies, especially if you are allergic to metronidazole.
- Tell your doctor if you have Crohn's disease, liver disease, kidney disease, or blood disorders.
- Metronidazole may cause dizziness. Do not operate machinery or drive a vehicle when new to metronidazole.
- Inform your doctor about medications, including supplements and herbal remedies, that you are currently or will be taking. Especially warfarin, busulfan, cimetidine, lithium, phenobarbital, and phenytoin.
- Tell your doctor if you are or have ever used disulfiram in the last 2 weeks. Usually metronidazole can not be used together with disulfiram because it can cause delusions and hallucinations.
- If an allergic reaction or overdose occurs, see a doctor immediately.
Dose and Rules of Use Metronidazole
The dose and form of the drug given by the doctor will be adjusted to the patient's condition. Here is the explanation:
Metronidazole drinking medicine
- Bacterial infection
7.5 mg/kg body weight, once every 6 hours, for 7-10 days or 2-3 weeks if the illness is severe enough.
- Bacterial Vaginosis
The doctor may prescribe one of these doses, according to the patient's condition:
Drugs taken 500 mg, as much as 2 times a day (for 7 days).
The drug is taken as a single dose of 2 g.
- Trichomoniasis
Doctors may prescribe one of these doses in adult patients:
250 mg every 8 hours (for 7 days).
2 g of a single dose of the drug.
1 g tablet or capsule once every 12 hours, for 2 days.
- Amebiasis
The dose for adult patients is 500-750 mg every 8 hours (for 5-10 days).
While the dose for children is 35-50 mg/kgBW, the dose is divided every 8 hours (for 10 days).
- Gardnerella infection
The dose for adult patients is 500 mg capsules once every 12 hours.
- Clostridium difficile colitisThe dose for pediatric patients is 30 mg/kgBW, divided doses every 6 hours (for 7-10 days).
- Giardiasis
The dose for pediatric patients is 15 mg/kgBW, divided doses every 8 hours (for 5 days).
Metronidazole infusion medicine
- Bacterial infection
The initial dose for adult patients is 15 mg/kg to 4 g/kg per day.
A follow-up dose of 7.5 mg/kgBW, infusion given over 1 hour, every 6 hours, for 7-10 days or 2-3 weeks if the condition is severe enough.
- Clostridium Difficile ColitisThe dose for pediatric patients is 30 mg/kgBW, the dose is divided every 6 hours, for 7-10 days.
- Giardiasis
The dose for pediatric patients is 15 mg/kg, divided doses every 8 hours for 5 days.
- Trichomoniasis
For children weighing under 45 kg: 15 mg/kg per day, divided doses every 8 hours for 7 days. Dosage should not exceed 2 g per day.
Metronidazole soup medicinepostoria
Bacterial infection
- Adults and children over 10 years: 1 g every 8 hours, for 3 days, then reduce to every 12 hours, for more than 3 days.
- Children under 1 year of age: 125 mg.
- Children 1-5 years: 250 mg.
- Children 5-10 years: 500 mg.
In addition to oral drugs, intravenous drugs, and suppositories, metronidazole is also available in the form of ovule drugs (tablets for the vagina). Ovules to treat bacterial vaginosis in adult patients are used once a day before bedtime for 5 days. Each ovule drug consists of 500 mg of metronidazole.
How to Use Metronidazole Correctly
Metronidazole in the form of infusion will be given by medical personnel at the hospital on doctor's instructions.
For metronidazole tablets, use as directed by your doctor. Take the drug with the help of food or a glass of water or milk to prevent heartburn.
Use ovules and suppositories as directed by your doctor, and don't forget to wash your hands before using the medicine.
For metronidazole ovules, use the applicator that comes in the box to insert the ovules into the vagina. Clean the ovule applicator after use.
For the suppository form of metronidazole, you can dip the medication in water first, to make it easier to insert into the rectum. Sit still or lie down for 15 minutes after using the medicine.
For those of you who forget to use metronidazole, it is recommended to use it as soon as you remember, if the break with the following schedule is not too close. If it is close, ignore it and do not double the dose.
Take the medicine your doctor has prescribed even if your symptoms subside. Stopping the use of metronidazole outside the schedule that has been set by the doctor can cause the infection to return. Go see your doctor again if your condition doesn't improve or it gets worse after the antibiotics are used up.
Store metronidazole in a place at room temperature, away from heat and humidity to prevent deterioration of the drug. Also, keep metronidazole out of the reach of children.
Metronidazole Interaksi Interactions with other drugs
There are several interactions that can occur if metronidazole is used together with other medicines, including:
- Causes nausea, vomiting, stomach cramps, and facial flushing when used with products containing alcohol, products containing propylene glycol, lopinavir/ritonavir, and lithium.
- Reduces the effectiveness of hormonal contraception, so that a person can get pregnant even though they are using contraception.
- Decreases the effectiveness of vaccines derived from live attenuated bacteria, such as typhoid vaccine.
- Increases risk of bleeding, when used with warfarin.
- Decreases the effectiveness of metronidazole, when used with phenobarbitol.
- Increases the side effects of metronidazole when used with cimetidine.
- Increases the risk of side effects from lithium, phenytoin, tacrolimus, and carbamazepine.
Side effects and DangerMetronidazole
Metronidazole can cause some side effects. The following side effects may occur due to the use of metronidazole:
- Dizzy
- Headache
- Nauseous
- Throw up
- Loss of appetite
- Diarrhea
- Constipation
- Bitter taste in mouth
- Changes in urine color to darker
Go to the ER at the hospital immediately if you feel serious symptoms such as the following:
- Numbness or tingling in the hands or feet
- Changes in behavior
- Feeling confused
- Difficult to speak
- Visual disturbance
- Huge headache
- Neck pain or stiffness
- Seizures