Esomeprazole is medicine to treat stomach acid disease or gastroesophageal reflux disease (GERD). In addition, this drug can also be used uTo treat Zollinger-Ellison syndrome, erosive esophagitis, or peptic ulcers.
Esomeprazole belongs to the class of proton pump inhibitor drugs that work by decreasing the production of stomach acid. To treat gastric ulcers due to infection Helicobacter pylori, this drug can be combined with amoxicillin and clarithromycin.
Esomeprazole trademarks: Arcolase, Depump, E-Some, Esola, Esozid, Esoferr, Esomax, Esomeprazole Sodium, Exocid, Ezol 20, Ezocon, Lanxium, Nexigas, Nexium MUPS, Proxium, Simprazole
What is Esomeprazole
| group | Prescription drugs |
| Category | Proton pump inhibitor |
| Benefit | Reduces stomach acid production |
| Used by | Adults and children 1 month old |
| Esomeprazole for pregnant and lactating women | Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. Esomeprazole is not known whether it can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Shape | Tablets and injections |
WarningBefore Using Esomeprazole
Esomeprazole should only be used as prescribed by a doctor. The following are things you need to pay attention to before using esomeprazole:
- Do not use esomeprazole if you are allergic to this drug or to other proton pump inhibitor class drugs, such as lansoprazole.
- Do not use esomeprazole if you are taking atazanavir, nelfinavir, rilpivirin drugs.
- Consult and discuss with your doctor about the use of esomeprazole in the elderly.
- Tell your doctor if you have or have had kidney disease, liver disease, lupus, vitamin B12 deficiency, osteoporosis, osteopenia, diarrhea, or hypomagnesemia.
- Tell your doctor if you are taking certain medications, supplements, or herbal remedies before taking esomeprazole.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Consult a doctor if diarrhea occurs after using esomeprazole, because this drug can increase the risk of developing due to bacterial infection Clostridium difficile.
- See your doctor right away if you have an allergic reaction to a drug, a more serious side effect, or an overdose after taking esomeprazole.
Dosage and Instructions for Use of Esomeprazole
The doctor will determine the dose and duration of treatment according to the patient's condition and age. Esomeprazole can be given in the form of oral drugs or injections through a vein (intravenous / IV). Here is the explanation:
tablet form
Condition: Gastroesophageal reflux disease (GERD) and erosive esophagitis
- Mature: 20–40 mg, once daily for 4 weeks. The maintenance dose is 20 mg, once daily for 6 months.
- Children aged 1–11 years weighing 10 kg until <20kg: 10 mg, once daily for 8 weeks.
- Children aged 1–11 years weighing 20 kg: 10–20 mg, once daily for 8 weeks. Maintenance dose 10 mg, once daily.
Condition: Zollinger-Ellison syndrome
- Mature: initial dose of 40 mg, 2 times a day, can be adjusted according to the patient's body response. The usual dose is 80–160 mg per day which can be given in 2 consumption schedules. The dose can be increased up to 240 mg per day.
Condition: Treatment and prevention of gastric ulcers due to NSAIDs
- Mature: 20–40 mg, once per day for 4–8 weeks.
Condition: Stomach ulcers caused by bacteria Helicobacter pylori
- Mature: 20 mg, twice daily for 7 days or 40 mg daily for ten days, given as therapy in combination with amoxicillin and clarithromycin.
- Children >4 years old weighing <30 kg: 10 mg, 2 times daily, in combination with amoxicillin and clarithromycin for 7 days.
- Children >4 years old weighing 30 kg: 20 mg, 2 times daily, in combination with amoxicillin and clarithromycin for 7 days.
Intravenous/IV injection form
Condition: Gastroesophageal reflux disease (GERD)
- Mature: 40 mg, once a day. Doses are given by slow injection over at least 3 minutes or by infusion over 10–30 minutes.
- Children ages 1–11 years: 10 mg, 1 time a day.
- Children aged 12–18 years: 20 mg, once a day.
Condition: Gastric ulcer and duodenal ulcer
- Mature: 80 mg daily, by infusion over 30 minutes. Subsequently, this may be followed by an infusion of 8 mg hourly for 72 hours.
Condition: Treatment of gastric ulcers due to NSAIDs
- Mature: 20 mg, once daily, by slow injection for at least 3 minutes or by infusion over 10–30 minutes.
How to Use Esomeprazole Correctly
Follow the doctor's instructions and always read the instructions on the packaging when using esomeprazole. Use esomeprazole according to the dose recommended by the doctor, do not increase or decrease the prescribed dose.
Esomeprazole should be taken 1 hour before meals for 14 days. Take the esomeprazole tablet with a glass of water to swallow the esomeprazole tablet.
Try to take esomeprazole at the same time every day and make sure there is enough time between one dose and the next, so that the effect is maximized.
For patients who forget to take esomeprazole, it is advisable to do so immediately if the interval between the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.
Esomeprazole injection should only be given by a doctor or medical personnel under the supervision of a doctor.
Store esomeprazole in a tightly closed storage area, at room temperature, and away from direct sunlight. Keep this medicine out of reach of children.
InteractionEsomeprazole with Other Drugs
Esomeprazole has the potential to cause drug interactions when used together with other drugs. Example:
- Decreased effectiveness of antiviral drugs, such as rilpivirine, atazanavir, or nelfinavir
- Increased risk of heart damage when used with digoxin
- Decreased effectiveness of the drug clopidogrel
- Increased risk of hypomagnesemia or decreased blood magnesium levels if taken with diuretic drugs
- Increased effectiveness of the drugs tacrolimus, methotrexate, or cilostazol
- Decreased absorption of drugs erlonitib, iron, or ketoconazole
- Increased risk of bleeding if used with warfarin
- Decreased effectiveness of esomeprazole when used with rifampicin
Side Effects and Dangers of Esomeprazole
The following are some of the common side effects that occur after using esomeprazole:
- Headache
- Nauseous
- bloating
- Stomach pain
- Diarrhea or constipation
- dry mouth
- Drowsiness
Check with your doctor if the side effects above do not subside. Immediately see a doctor if you have an allergic reaction to the drug or a more serious side effect, such as:
- Severe stomach pain and diarrhea that doesn't go away or bleeds
- Kidney disorders that can be characterized by symptoms, such as difficulty urinating, bloody urine, swelling in the legs
- Low magnesium levels, which can be characterized by symptoms, such as dizziness, fast or irregular heartbeat, tremors, muscle cramps, or stiffness in the hands or feet
Long-term use of esomeprazole can increase the risk of vitamin B12 deficiency or bone fractures. Follow the doctor's advice while undergoing treatment with esomeprazole.