Fibrinogen or factor I is a plasma protein that plays an important role in blood clotting. Fibrinogen can givento overcomeheavy bleeding due to injury, DIC (disseminated intravascular coagulation), or congenital abnormalities, such as afibrinogenemia or hypofibrinogenemia.
Fibrinogen is naturally produced by the liver and is found in blood plasma. This protein plays a role in the blood coagulation process along with thrombin, plasmin, and factor XIIIa. Fibrinogen can be found in blood transfusion products, such as FFP (fresh frozen plasma), cryoprecipitate, or in the form Fibrinogen concentrate.
Trademark fibrinogen: Beriplast P Combi-Set
What is Fibrinogen
| group | Prescription drugs |
| Category | blood components |
| Benefit | Overcome fibrinogen deficiency |
| Used by | Adults and children |
| Fibrinogen for pregnant and lactating women | Category N: Not yet categorized. Fibrinogen is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use fibrinogen without consulting your doctor first. |
| Shape | Injections and blood components |
Precautions Before Using Fibrinogen
There are several things you should pay attention to before using fibrinogen, including:
- Tell your doctor about any allergies you have. Fibrinogen should not be given to patients who are allergic to this protein.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- Tell your doctor if you have or are currently suffering from a stroke or blockage in a blood vessel.
- See your doctor immediately if you have an allergic reaction or serious side effect after taking fibrinogen.
Dosis and Rules for Use Fibrinogen
Fibrinogen will be given directly by a doctor or medical officer under the supervision of a doctor. This blood transfusion product is usually given in a health facility or hospital.
Fibrinogen can be found in blood transfusion products such as cryoprecipitate. The dosage may vary depending on the patient's condition. In general, if you use cryoprecipitate, the dose is 10 units and can be repeated if needed. Giving 1 unit cryoprecipitate able to increase the amount of fibrinogen about 100 mg/dL.
Fibrinogen is also available in injectable form. Fibrinogen injection can be done through a vein (intravenous / IV). The dose will be adjusted according to the patient's condition.
How to Use Fibrinogen Correctly
Fibrinogen will be given directly by a doctor or medical officer under the supervision of a doctor. Follow the advice given by the doctor while undergoing treatment with fibrinogen.
While taking fibrinogen, you may be asked to have regular blood tests.
Interaction Fibrinogen with Other Drugs
It is not known the effect of interactions that arise due to the use of fibrinogen with other drugs. To be on the safe side, tell your doctor if you are taking certain medications, supplements, or herbal products.
Side Effects and Dangers Fibrinogen
During treatment with fibrinogen, your condition will be monitored by a doctor or medical officer. There are several side effects that can occur after using fibrinogen, namely:
- Fever
- Shivering
- Headache
- Nausea and vomiting
Report to your doctor or medical officer if the side effects mentioned above do not subside or get worse.
In addition, the use of fibrinogen can increase the risk of pulmonary embolism, deep vein thrombosis, arterial thrombosis, and myocardial infarction.. Tell your doctor right away if you have any symptoms of any of these conditions or have an allergic reaction after taking fibrinogen.