Norepinephrine or noradrenaline is a drug for treat life-threatening acute low blood pressure (hypotension). In addition, norepinephrine can also be used in the treatment of cardiac arrest.
Norepinephrine has an effect on both alpha and beta receptors. This medicine will constrict blood vessels so that it can increase blood pressure. In addition, norepinephrine can also trigger the heart's work in pumping blood.
Norepinephrine will generally be given in an emergency. This drug is available in injectable form. Keep in mind that this medicine should only be given by a doctor or medical personnel under the supervision of a doctor.
Merek trade norepinephrine:Arespin, Epinor, Epivas, Efrala, Guprin, Norfion, Norepinephrine Bitartrate, Norepinephrine Bitartrate Monohydrate, Raivas, Vascon
What is Norepinephrine
| group | Prescription drugs |
| Category | Alpha and beta agonists/vasoconstrictors |
| Benefit | Treats life-threatening hypotension and treats cardiac arrest |
| Used by | Mature |
| Norepinephrine for pregnant and lactating women | Category C:Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. Norepinephrine is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first. |
| Drug form | Inject |
WarningBefore Using Norepinephrine
Norepinephrine will usually be used in a hospital in an emergency. There are several things to consider before using this drug, including:
- Tell your doctor about any allergies you have. Norepinephrine should not be given to patients who are allergic to this drug.
- Norepinephrine is generally given in an emergency, if possible, tell your doctor if you have or are currently suffering from hypertension, diabetes, coronary heart disease, varicose veins, hyperthyroidism, or asthma.
- Tell your doctor if you are taking certain medications, supplements, or herbal products.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- See your doctor right away if you experience an allergic drug reaction, a more serious side effect, or an overdose after taking norepinephrine.
Norepinephrine Dosage and Usage
Norepinephrine will be given by a doctor or medical officer under the supervision of a doctor in a hospital. The dose and duration of treatment will be determined according to the goals and conditions of the patient.
In general, the following are the dosages of norepinephrine for adult patients based on their intended use:
- Purpose: Treating acute hypotension
Initial dose 8–12 mcg per minute, by infusion. The dose can be increased to achieve the desired therapeutic response. Maintenance dose 2–4 mcg per minute, by infusion.
- Purpose: Treat cardiac arrest
Initial dose 8–12 mcg per minute, by infusion. The dose can be increased to achieve the desired therapeutic response. Maintenance dose 2–4 mcg per minute, by infusion.
In addition, norepinephrine can also be used in the treatment of septic shock, at a dose of 0.01–3.3 mcg/kgBW per minute, by infusion.
How to use Norepinephrine correctly
Norepinephrine injection will be given in a hospital and injected through an IV into a vein (intravenous / IV). While the patient is infused with this drug, the doctor will monitor the patient's condition, especially blood pressure, heart rate, and respiratory rate.
If his condition has improved after being given norepinephrine, the patient will receive further treatment from the doctor. The dose and duration of use of norpineprine may vary from patient to patient.
InteractionNorepinephrine with Drug Other
The following are some of the effects of interactions that may occur when taking norepinephrine with other drugs:
- Increased risk of arrhythmias when used with anesthetic drugs, such as desflurane, enflurane, or halothane
- Increased risk of hypertensive crisis if used with drugs monoamine oxidase inhibitors (MAOI) or dihydroergotamine
- Increased risk of side effects, such as hypertension, severe headache, tremor, palpitations, or chest pain, when used with tricyclic antidepressants, such as amitriptyline or amoxapine
- Decreased effectiveness of norepinephrine with nonselective beta-blocking drugs, such as carvedilol or propranolol
- Increased blood pressure when used with methyldopa or guanethidine
Norepinephrine Side Effects and Dangers
The doctor will monitor closely during and after the norepinephrine injection. Some of the side effects that can occur after using norepinephrine are:
- Pain, burning, irritation, skin discoloration, at the injection site
- Numbness, weakness, or feeling cold
- Slow, fast, or irregular heartbeat
- Cyanosis or bluish lips and nails
- Headache, blurred vision, slurred speech, or difficulty maintaining balance
- Confusion, anxiety, shaking (tremor), unusually tired, or excessive sweating
Report to your doctor or medical officer if any of the side effects mentioned above occur. Tell your doctor right away if you have an allergic reaction to the drug, which can be characterized by symptoms such as an itchy rash, difficulty breathing, or swelling of the eyelids or lips.